electrochemical behaviour of nifedipine and nitrendipine in chloroform and chloroform-isopropanol mixture
نویسندگان
چکیده
the electrochemical behavior of nifedipine (i), nitrendipine(ii) and their photodegradation products has been studied by employing electrochemical techniques in chloroform and in 1:4 mixture of chloroform-isopropanol using piperidinium perchlorate (ppc) as supporting electrolyte. it has been shown that i and ii undergo in a 4e, 4h+ irreversible reduction reaction, while the reduction product, phenylhydroxylamine, is oxidized in a 2e, 2h+ reversible process to an unstable nitrosophenyl compound. photodegradation of i and ii by sunlight produces a nitrosophenyl derivative which is reversibly reduced to the corresponding unstable phenylhydroxylamine. no significant change is observed in electrochemical properties of drugs by passing from chloroform to chloroform-isopropanol mixture. the possibility of analysis of i and ii by dp polarography is also verified.
منابع مشابه
Electrochemical Behaviour of Nifedipine and Nitrendipine in Chloroform and Chloroform-Isopropanol Mixture
The electrochemical behavior of nifedipine (I), nitrendipine(II) and their photodegradation products has been studied by employing electrochemical techniques in chloroform and in 1:4 mixture of chloroform-isopropanol using piperidinium perchlorate (PPC) as supporting electrolyte. It has been shown that I and II undergo in a 4e, 4H+ irreversible reduction reaction, while the reduc...
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عنوان ژورنال:
iranian journal of chemistry and chemical engineering (ijcce)ناشر: iranian institute of research and development in chemical industries (irdci)-acecr
ISSN 1021-9986
دوره 17
شماره 1 1998
کلمات کلیدی
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